Reproductive alterations in male rats exposed perinatally to Solanum lycocarpum fruits

Authors

  • Aline Schwarz Universidade Federal do Rio Grande do Norte, Departamento de Análises Clínicas e Toxicológicas, Natal, RN
  • Wilma De Grava Kempinas Universidade Estadual Paulista, Instituto de Biociências, Departamento de Morfologia, Botucatu, SP
  • Milena Rodrigues Soares Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Maria Martha Bernardi Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP
  • Helenice de Souza Spinosa Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Patologia, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.2009.26762

Keywords:

Solanum lycocarpum, Solasodine, Reproductive function, Fertility, Sperm production, Rat

Abstract

This work employed pregnant rats treated with Solanum lycocarpum unripe fruits (10% in diet) from gestation day (GD) 06 to post-natal day (PND) 07, for the evaluation of the sperm number, daily sperm production and epididymal sperm transit time of the male offspring at PND 60 and PND 90. No differences were observed in the daily sperm production (DSP) and sperm number in the testis of the exposed males at PND 60 and PND 90. Also, no alterations were observed in sperm transit time in the caput epididymis of the exposed males at PND 60 and PND 90. However, a reduced sperm transit time was observed in the corpus/cauda epididymis of the experimental males at PND 90. The last data may explain the reduced sperm number observed in the corpus/cauda epididymis of the experimental male rats at PND 90. These data show that the male rats exposed to S. lycocarpum fruits during gestation did not present alterations in testis sperm production and number, however the sperm transit time through epididymis was impaired, resulting in a decreased number of spermatozoa in epididymis cauda. We conclude that S. lycocarpum may cause imbalance on hypothalamus-pituitary gland axis

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Published

2009-04-01

Issue

Vol. 46 No. 2 (2009)

Section

UNDEFINIED

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Schwarz A, Kempinas WDG, Soares MR, Bernardi MM, Spinosa H de S. Reproductive alterations in male rats exposed perinatally to Solanum lycocarpum fruits. Braz. J. Vet. Res. Anim. Sci. [Internet]. 2009 Apr. 1 [cited 2025 Jan. 14];46(2):152-7. Available from: https://www.revistas.usp.br/bjvras/article/view/26762