Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
Keywords:Vitamin C, Vitamin E, Copper cumulative poisoning, Oxidative Stress, Amonium tetrathiomolybdate (TTM)
AbstractThe effects of vitamins C and/or E associated to amonium tetrathiomolybdate (TTM) in the treatment of cumulative copper intoxication (ICC) in sheep were analyzed throughout oxidative metabolism. Reduced glutathione (GSH), malondialdehyde (MDA), uric acid and the ferric reducing ability of plasma (FRAP) concentrations were evaluated. Twenty four male sheep, Santa Ines breed, with 25 kg BW was distributed in four treatments: TTM, TTM and vitamin C (TTM+VC), TTM with vitamin E (TTM+VE) and TTM with vitamins C and E (TTM+VCE). The intoxication status caused an intensive formation of free radicals with reduction of the GSH concentration and increase of MDA. Despite the increase in the capacity of plasmatic antioxidant observed with the increase of uric acid and FRAP concentrations, it was not observed any benefit with treatments using oxidant vitamins, isolatedly or together with classic treatment only with TTM.
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How to Cite
Weigel, R. A., Ortolani, E. L., & Sucupira, M. C. A. (2010). Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins. Brazilian Journal of Veterinary Research and Animal Science, 47(6), 421-428. https://doi.org/10.11606/issn.1678-4456.bjvras.2010.26803
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