Use of DNA markers for genomic diagnosis of domestic animals: 2. Detection of point mutation causing Hyperkalemic Periodic Paralysis (HYPP) in Quarter horses
Keywords:Paralysis, Hyperkalemia, Horses, Equidae, DNA.
AbstractTwelve Quarter horses, descendants from Impressive line, have been analyzed. DNAs, purified from leukocytes of those animals, were submitted to Polymerase Chain Reaction technique (PCR) and digested by Taq I restriction
enzyme. Accordingly the Hyperkalemic Periodic Paralysis (HYPP) genomic diagnosis was established. The tests revealed that 9 animals were carrier heterozygotes (N/H) and 3 normal homozygotes (N/N). Since the development of PCR methodology, it has been possible to diagnose the problem and plan ways to control the spreading of this defective gene in the population, through detection of carrier and normal animals.
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Garcia, J. F., Gurgel, A. S. do A., Visintin, J. A., Lunge, V. R., Duarte, M. B., & Bertolli, J. L. (1996). Use of DNA markers for genomic diagnosis of domestic animals: 2. Detection of point mutation causing Hyperkalemic Periodic Paralysis (HYPP) in Quarter horses. Brazilian Journal of Veterinary Research and Animal Science, 33(3), 136-139. https://doi.org/10.11606/issn.2318-3659.v33i3p136-139
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