Comparative evaluation of the effects of a new biological adhesive (Colagel) on the tensile strength and healing of intestinal anastomoses
Keywords:Experimental surgery of dogs, Intestines surgery (repair)
The effects of a new biological adhesive based on a mixture of gelatin-resorcin and formaldehyde (Colagel) for use as an adjuvant in the reinforcement, impermeabilization and healing of intestinal anastomoses were evaluated and compared to those obtained with omentun fixation, the standard procedure used for this purpose. Two ileal anastomoses were performed in each of 12 experimental dogs using an extramucosal technique and single plane sutures. One of the anastomoses in each animal was covered with adhesive and the other with omentun, in random order. The anastomosed intestinal segments were tested for tensile strength and analysed histopathologically 1, 3, 7, 14, 21 and 28 days after surgery. The tensile strength of the anastomoses treated by the two different procedures was statistically identical. Histopathology revealed normal healing evolution for both procedures on days 1, 3 and 7, and greater exudation in the adhesive group on days 14, 21 and 28 after surgery.
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