Behavioral and biochemical effects of xylazine: possible interactions between central noradrenergic-dopaminergic systems
Keywords:Xylazine, Behavior (animal), Stereotyping, Catatonia
Behavioral and biochemical effects of xylazine were studied both in rats and mice. The results showed that xylazine: a) decreased the general activity of rats and mice observed in an open field; b) was unable to produce catatonia and suppressed haloperidol-induced catatonia in mice; c) increased apomorphine-induced stereotyped behavior in rats; and d) increased brain noradrenaline without effect on brain dopamine levels. These results were discussed in the light of a possible interference of xylazine with brain noradrenergic system and, thus, with the dynamic interaction between noradrenergic-dopaminergic neurons within the Central Nervous System.
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