Regulação da expressão gênica nas engrenagens do relógio circadiano de mamíferos
DOI:
https://doi.org/10.11606/issn.1984-5154.v4p28-33Palavras-chave:
Ritmo circadiano, regulação gênica, núcleos supraquiasmáticos, genes relógios.Resumo
A manifestação de ritmos biológicos nos mais diversos organismos é reconhecida desde a antiguidade, mas os princípios básicos responsáveis por sua geração começaram a ser desvendados somente no século passado, e continuam até os dias atuais. Nesse contexto, um grande marco foi a descoberta de uma rede de genes cujos processos de transcrição e tradução são regulados entre si e que constituem a maquinaria básica do sistema oscilatório endógeno. Esta revisão visa descrever o funcionamento desta maquinaria em mamíferos, detalhando seus atuais componentes e como isso se propaga para todo o organismo.
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