Dengue vaccines

Abstract

The control of dengue is done world-wide by fighting the vector mosquito following the rules preconized by sanitarians of the beginning of the century. The control and the eradication of Aedes aegypti, the principal vector of dengue, is extremely difficult and demand large money investing on personnel, machines, insect poisons and permanent educational campaigns. The best alternative for dengue control is the use of vaccines. In this revision work the research on dengue vaccines is analyzed, including: attenuated viruses; genetic engineering (recombinant vaccines) by virus protein expression in euchariotic cells, recombinant viruses, mutant and chimera viruses, vaccines with living vectors, and DNA vaccines. The attenuated dengue virus vaccines have best chances of a generalized use in the next years.