Heart implantation in subcutaneous tissue of isogenic mice. Study of an experimental model

Authors

  • José Luiz Laus Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal, SP
  • Ricardo Ribeiro Santos Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP
  • Marco Antonio Rossi Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP
  • Maria Meira Oliveira Rossi Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1991.51938

Keywords:

Implantation of heart, Experimental surgery, Mice

Abstract

An experimental model of heart implantation in mice was studied, in accordance to the feasibility, post-surgical kinetics by histopathology and practical application. Isogenic animals from BALB/c and C57BL/10 strains were used, supplied by the Animal House of the Department of Parasitology, Microbiology and Imnunology of FMRP-USP. The experimental protocols were performed according to the operatory steps of the implantation of hearts extracted from just-born donors to the subcutaneous space of the dorsal face of the ear of adult singeneic and non singeneic receptors. Obtained results showed, basically, good feasibility and success in singeneic implantation. For non singeneics, there was sistematic rejection. The analysis altogether of the studied parameters allows to foresee the great utility of the model and the subsides that will bring to further studies in the field of alotransplantation.

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Published

1991-12-02

How to Cite

Laus, J. L., Santos, R. R., Rossi, M. A., & Rossi, M. M. O. (1991). Heart implantation in subcutaneous tissue of isogenic mice. Study of an experimental model. Brazilian Journal of Veterinary Research and Animal Science, 28(2), 191-200. https://doi.org/10.11606/issn.1678-4456.bjvras.1991.51938

Issue

Section

ANIMAL PATHOLOGY

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