Efeitos secundários potencialmente desejáveis dos anestésicos locais

Autores

  • Estela Maris Freitas Muri Universidade Federal Fluminense. Faculdade de Farmácia
  • Maria Matilde de Mello Sposito Universidade de São Paulo. Faculdade de Medicina
  • Leonardo Metsavaht Instituto Brasil de Tecnologias da Saúde

DOI:

https://doi.org/10.11606/issn.2317-0190.v17i1a103307

Palavras-chave:

Anestésicos Locais/farmacologia, Canais de Sódio, Literatura de Revisão como Assunto

Resumo

Apesar do uso dos anestésicos locais (ALs) ter a finalidade principal de produzir bloqueios nervosos pela inibição dos canais de Na+, a literatura tem mostrado que esses agentes podem ter ações farmacológicas adicionais, afetando também, os canais de potássio e de cálcio e agindo em mecanismos intracelulares. Os ALs podem, além de causar anestesia, agir diretamente sobre outros receptores e suas vias de sinalização que estão envolvidos nos processos de inflamação, ativação plaquetária, nocicepção, dor periférica e arritmias, dentre outras, buscando cada vez mais, uma melhor eficácia e segurança clínica, além de novas e potencialmente úteis propriedades para os ALs. Assim, o objetivo deste estudo foi pesquisar em literatura científica e descrever uma revisão da farmacologia e dos efeitos adicionais potencialmente desejáveis dos principais anestésicos locais usados na clínica médica.

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Publicado

2010-03-09

Edição

Seção

Artigo de Revisão

Como Citar

1.
Muri EMF, Sposito MM de M, Metsavaht L. Efeitos secundários potencialmente desejáveis dos anestésicos locais. Acta Fisiátr. [Internet]. 9º de março de 2010 [citado 23º de abril de 2024];17(1):28-33. Disponível em: https://www.revistas.usp.br/actafisiatrica/article/view/103307