Suplementação de creatina como potencial agente terapêutico na reabilitação da doença arterial obstrutiva periférica

Autores

  • Lucas Caseri Câmara Universidade Federal de São Paulo
  • Erika Magalhães Suzigan Santa Casa de Misericórdia de São Paulo
  • Marcelo Andrade Starling Universidade Federal de São Paulo

DOI:

https://doi.org/10.5935/0104-7795.20130025

Palavras-chave:

Creatina, Doença Arterial Obstrutiva Periférica/reabilitação, Claudicação Intermitente

Resumo

Suplementação de Creatina (Cr) têm sido utilizada de forma segura e eficaz em diversas condições de saúde e doença, incluindo fraqueza, atrofia e distúrbios metabólicos musculares. Na doença arterial obstrutiva periférica (DAOP), a isquemia crônica promove atrofia, denervação e prejuízos metabólicos musculares, reduzindo a força e resistência, prejudicando a aptidão física geral. Tomando em conjunto, os benefícios conhecidos da suplementação de Cr e a apresentação clínica da DAOP, apresentam a suplementação de Cr como potencial agente terapêutico a ser considerado. Objetivo: Realizar uma revisão sistemática da literatura científica procurando por estudos envolvendo a suplementação de Cr em portadores de DAOP, publicados nos últimos dez anos. Método: Uma pesquisa por artigos escritos em português e inglês no período descrito, incluindo o cruzamento de termos relacionados a DAOP e a suplementação de Cr foi realizada no PubMed, SciELO, e LILACS. Resultados: Um único estudo avaliou a influência da suplementação de Cr na amostra desejada (DAOP), descrevendo efeitos positivos na distância de caminhada e em propriedades sanguíneas. Devido à escassez de dados sobre o tema, o potencial uso da Cr na DAOP incluindo considerações metabólicas, funcionais e estruturais foi discutido. Conclusão: Apesar das apresentadas considerações para a utilização da Cr como potencial agente terapêutico na DAOP, apenas um estudo prévio verificou benefícios. Assim ainda há uma grande lacuna na literatura científica, deixando campo aberto para futuros estudos na procura de possíveis benefícios no combate a perda funcional, prejuízo da estrutura e metabolismo muscular de indivíduos doentes.

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2013-09-09

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1.
Câmara LC, Suzigan EM, Starling MA. Suplementação de creatina como potencial agente terapêutico na reabilitação da doença arterial obstrutiva periférica. Acta Fisiátr. [Internet]. 9º de setembro de 2013 [citado 21º de julho de 2024];20(3):152-6. Disponível em: https://www.revistas.usp.br/actafisiatrica/article/view/103786