Comparison of neuromuscular and biochemical responses between patients with COPD and healthy subjects

Authors

  • Natércia Ferreira de Queiroz Universidade Federal do Rio Grande do Norte
  • Rudolfo Hummel Gurgel Vieira Universidade Federal do Rio Grande do Norte
  • Wouber Hérickson de Brito Vieira Universidade Federal do Rio Grande do Norte
  • Zênia Trindade de Souto Araujo Universidade Federal do Rio Grande do Norte
  • Gerson Fonseca de Souza Universidade Federal do Rio Grande do Norte
  • Ivan Daniel Bezerra Nogueira Universidade Federal do Rio Grande do Norte
  • Telma Maria Araújo Moura Lemos Universidade Federal do Rio Grande do Norte
  • Patrícia Angélica de Miranda Silva Nogueira Universidade Federal do Rio Grande do Norte

DOI:

https://doi.org/10.11606/issn.2317-0190.v30i4a194247

Keywords:

Pulmonary Disease, Chronic Obstructive, Biomarkers, Muscle Fatigue, Quadriceps Muscle

Abstract

Objective: To compare neuromuscular and biochemical responses of femoral quadriceps muscle damage and fatigue between chronic obstructive pulmonary disease (COPD) and healthy subjects. Methods: Observational, transversal and comparative study. The sample consisted of 18 subjects assigned to two distinct groups: COPD group (CG) and healthy group (HG), who were assessed by spirometry, quadriceps neuromuscular performance, biochemical markers of muscle damage and fatigue, fatigability and muscle pain. Results: Statistically significant difference was observed in mean power between CG and HG (99.9 ± 21.0 vs. 145.1 ± 51.5, respectively; p= 0.02) and a tendency of mean peak torque (85.7 ± 24.4 vs 104.4 ± 31.0, p= 0.45) and total work (1,305.5 ± 329.9 vs 1.671.5 ± 444.5; p= 0.06) were smaller in the CG than HG, respectively. The LDH concentration immediately after the isokinetic test was significantly higher in the CG than HG (402.3 ± 33.6 vs 289.4 ± 33.6, respectively; p= 0.03). Conclusions: The present study showed that patients with COPD have a reduced ability to generate force over a given period of time when compared to healthy subjects. The plasma levels of biochemical markers did not confirm that patients with COPD have a higher level of muscle damage when exercising than healthy controls.

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Published

2023-12-31

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Vol. 30 No. 4 (2023)

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Original Article

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How to Cite

1.
Queiroz NF de, Vieira RHG, Vieira WH de B, Araujo ZT de S, Souza GF de, Nogueira IDB, et al. Comparison of neuromuscular and biochemical responses between patients with COPD and healthy subjects. Acta Fisiátr. [Internet]. 2023 Dec. 31 [cited 2024 May 21];30(4):218-24. Available from: https://www.revistas.usp.br/actafisiatrica/article/view/194247